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Enzalutamide, the first approved ar signalling inhibitor, has a novel mode of action targeting ar signalling at three key stages

The direct mode of action of enzalutamide has been shown to translate into clinical responses in patients with mcrpc. Enzalutamide, the first approved ar signalling inhibitor, has a novel mode of action targeting ar signalling at three key stages. Enzalutamide is the first approved ar signalling inhibitor (also described as an ar inhibitor), with a novel mechanism of action, that distinguishes it from both androgen biosynthesis inhibitors (e.g Results from the randomised, phase 3 affirm trial. European society for medical ncology magnitude of clini y ni, dafni u, bogaerts j et l.