Abstract the farnesoid x receptor (fxr) is a nuclear receptor (nr) known to obligately heterodimerize with the retinoid x receptor (rxr) On the contrary, giaginis et al Found that an elevated fxr expression is associated with lower tumor aggressiveness and a more favorable prognosis in patients with pancreatic adenocarcinoma [121]. To date, the structural basis and functional consequences of the fxr/rxr heterodimer interaction have remained unclear It is suggested that fxr and rxrs were implicated in pancreatic malignant disease progression, reinforcing their utility as clinical markers for patients' management and prognosis, as well as targets for potential therapeutic interventions.
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