The size of deletions in the long arm of chromosome 13 varies widely Large 13q14 deletions are associated with aggressive tumors and poor outcomes compared to short deletions [8]. Chronic lymphocytic leukemia (cll) with deletion 13q (del13q) has historically better outcome after chemotherapy However a sizeable number of such patients do progress with a decreased progression free survival (pfs) and overall survival (os). The most frequent changes were a deletion in 13q (55 percent), a deletion in 11q (18 percent), trisomy of 12q (16 percent), a deletion in 17p (7 percent), and a deletion in 6q (6 percent). However, significant heterogeneity in del (13q) aberrations has been observed among cll patients with isolated del (13q), which should be considered when predicting prognosis and planning clinical management for individual cll patients with this aberration.
Summary deletion 13q14 on fluorescence in situ hybridization (fish) analysis is the most common cytogenetic abnormality in chronic lymphocytic leukemia (cll), and is a favorable prognostic biomarker when detected as a sole abnormality This significant 13q14 deletion contributes to cll's pathogenesis and paves the way for cll treatment, hence affecting the prognosis of the affected patients Furthermore, the size of deletion of the long arm of chromosome 13 (13q) has a remarkable effect on its prognosis and therapeutic intervention.
WATCH
