Abstract background neurosyphilis, resulting from treponema pallidum (t Pallidum) invasion of the central nervous system, is characterized by neuroinflammation and abnormal angiogenesis Pallidum protein tp47 has been shown to modulate microglial function, however, its specific role in neurovascular remodeling remains to be elucidated. In this review, we integrate this eclectic body of information to garner fresh insights into the highly successful parasitic lifestyles of the syphilis spirochete and related pathogenic treponemes. Treponema pallidum, the causative agent of syphilis, exhibits unique metabolic characteristics, including the absence of a fully functional tca cycle, which raises questions about how it sustains its high motility with limited atp production. Treponema pallidum is a spirochetal bacterium that belongs to the genus treponema
Within this genus, there are several subspecies and related organisms, each responsible for distinct diseases in humans. Causative agents of endemic treponematoses comprise treponema pallidum subsp Pertenue (agent of yaws), treponema pallidum subsp Endemicum (agent of bejel) and t
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